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Compound Detail

CHEMBL2236650

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COc1ccc(OC)c(/C=C/C(=O)c2ccco2)c1

Basic Information

ChEMBL ID CHEMBL2236650
Phase Preclinical
Structure Type MOL
InChI Key OLBVWHWSOQKFOA-FNORWQNLSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
15
Publications
0
Known Names

Molecular Properties

258.3
MW (Da)
3.19
ALogP
4
HBA
0
HBD
48.7
PSA (Ų)
0.61
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H14O4
MW 258.27
Aromatic Rings 2
Heavy Atoms 19
NP-Likeness -0.52

Activity Summary

IC50 2 meas. best 4.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
RAW264.7
CHEMBL612557
IC50 4.8 4.795 15848.9 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1007/s00044-011-9706-1 RAW264.7 2
- 10.1007/s00044-012-0401-7 Staphylococcus aureus 2
- 10.1007/s00044-011-9733-y Candida albicans 1
- 10.1007/s00044-011-9733-y Aspergillus niger 1
- 10.1007/s00044-011-9733-y Pseudomonas aeruginosa 1
- 10.1007/s00044-011-9733-y Salmonella typhi 1
- 10.1007/s00044-011-9733-y Escherichia coli 1
- 10.1007/s00044-011-9733-y Staphylococcus aureus 1
- 10.1007/s00044-011-9733-y Bacillus subtilis 1
- 10.1007/s00044-011-9733-y HEp-2 1
- 10.1007/s00044-011-9733-y IMR-32 1
- 10.1007/s00044-011-9733-y OVCAR 1
- 10.1007/s00044-011-9733-y PC-3 1
- 10.1007/s00044-012-0401-7 Radical scavenging activity 1
- 10.1007/s00044-012-0401-7 Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine