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Assay Detail

CHEMBL3062809

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anti-inflammatory activity in Mus musculus (mouse) RAW264.7 cells assessed as inhibition of IFN-gamma/LPS-induced NO production after 17 to 20 hr by Griess assay
ChEMBL ↗
61
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type RAW264.7
Confidence 1 — Organism
Curated By Autocuration

Target

RAW264.7 (CHEMBL612557) ↗
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and QSAR analysis of chalcone derivatives as nitric oxide inhibitory agent
Lam KW, Uddin R, Liew CY, Tham CL, Israf DA, Syahida A, Rahman MBA, Ul-Haq Z, Lajis NH
Med Chem Res (2012) 21 : 1953 -1966
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 61 4.90 5.65

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2262155 — — 2 5.65
CHEMBL2262149 — — 2 5.60
CHEMBL2262153 — — 2 5.35
CHEMBL2262154 — — 2 5.28
CHEMBL2262152 — — 2 5.25
CHEMBL2262146 — — 2 5.23
CHEMBL2262156 — — 2 5.19
CHEMBL2420693 — — 2 5.11
CHEMBL2261901 — — 1 5.10
CHEMBL2262147 — — 2 5.03
CHEMBL2420694 — — 2 4.94
CHEMBL378104 CARDAMOMIN — 1 4.94
CHEMBL2262157 — — 2 4.89
CHEMBL2261902 — — 1 4.87
CHEMBL2261900 — — 1 4.86
CHEMBL2262151 — — 2 4.84
CHEMBL2236650 — — 2 4.80
CHEMBL2262148 — — 2 4.79
CHEMBL2420784 — — 2 4.79
CHEMBL1975751 — — 1 4.79
CHEMBL2261896 — — 2 4.77
CHEMBL1438596 — — 2 4.77
CHEMBL1577632 — — 2 4.71
CHEMBL2261899 — — 2 4.67
CHEMBL7890 L-NAME 2.0 1 4.63
CHEMBL2261910 — — 1 4.63
CHEMBL2261913 — — 2 4.61
CHEMBL2261914 — — 2 4.60
CHEMBL2261895 — — 1 4.58
CHEMBL2261904 — — 1 4.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2262155 — IC50 = 2238.72 nM 5.65
CHEMBL2262155 — IC50 = 2260.0 nM 5.65
CHEMBL2262149 — IC50 = 2511.89 nM 5.60
CHEMBL2262149 — IC50 = 2510.0 nM 5.60
CHEMBL2262153 — IC50 = 4470.0 nM 5.35
CHEMBL2262153 — IC50 = 4466.84 nM 5.35
CHEMBL2262154 — IC50 = 5310.0 nM 5.28
CHEMBL2262152 — IC50 = 5623.41 nM 5.25
CHEMBL2262152 — IC50 = 5620.0 nM 5.25
CHEMBL2262146 — IC50 = 5880.0 nM 5.23
CHEMBL2262156 — IC50 = 6456.54 nM 5.19
CHEMBL2262156 — IC50 = 6450.0 nM 5.19
CHEMBL2262146 — IC50 = 6918.31 nM 5.16
CHEMBL2420693 — IC50 = 7760.0 nM 5.11
CHEMBL2420693 — IC50 = 7762.47 nM 5.11
CHEMBL2261901 — IC50 = 7960.0 nM 5.10
CHEMBL2262147 — IC50 = 9350.0 nM 5.03
CHEMBL2262147 — IC50 = 9332.54 nM 5.03
CHEMBL2420694 — IC50 = 11481.54 nM 4.94
CHEMBL378104 CARDAMOMIN IC50 = 11480.0 nM 4.94
CHEMBL2420694 — IC50 = 11480.0 nM 4.94
CHEMBL2262154 — IC50 = 12302.69 nM 4.91
CHEMBL2262157 — IC50 = 12882.5 nM 4.89
CHEMBL2262157 — IC50 = 12870.0 nM 4.89
CHEMBL2261902 — IC50 = 13500.0 nM 4.87
CHEMBL2261900 — IC50 = 13780.0 nM 4.86
CHEMBL2262151 — IC50 = 14510.0 nM 4.84
CHEMBL2262151 — IC50 = 14454.4 nM 4.84
CHEMBL2236650 — IC50 = 15848.93 nM 4.80
CHEMBL2262148 — IC50 = 16218.1 nM 4.79
CHEMBL2420784 — IC50 = 16218.1 nM 4.79
CHEMBL2236650 — IC50 = 16020.0 nM 4.79
CHEMBL2420784 — IC50 = 16060.0 nM 4.79
CHEMBL1975751 — IC50 = 16220.0 nM 4.79
CHEMBL2262148 — IC50 = 16290.0 nM 4.79
CHEMBL1438596 — IC50 = 17040.0 nM 4.77
CHEMBL1438596 — IC50 = 16982.44 nM 4.77
CHEMBL2261896 — IC50 = 16982.44 nM 4.77
CHEMBL2261896 — IC50 = 16980.0 nM 4.77
CHEMBL1577632 — IC50 = 19498.45 nM 4.71
CHEMBL1577632 — IC50 = 19330.0 nM 4.71
CHEMBL2261899 — IC50 = 21379.62 nM 4.67
CHEMBL2261899 — IC50 = 21310.0 nM 4.67
CHEMBL2261910 — IC50 = 23430.0 nM 4.63
CHEMBL7890 L-NAME IC50 = 23210.0 nM 4.63
CHEMBL2261913 — IC50 = 24547.09 nM 4.61
CHEMBL2261913 — IC50 = 24760.0 nM 4.61
CHEMBL2261914 — IC50 = 24890.0 nM 4.60
CHEMBL2261914 — IC50 = 25118.86 nM 4.60
CHEMBL2261895 — IC50 = 26040.0 nM 4.58