Compound Detail
CHEMBL225852
GLAUCINE METHIODIDE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL225852 |
| Name | GLAUCINE METHIODIDE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JTGJUUGXOWUVQG-NTISSMGPSA-M |
| Parent Compound | CHEMBL1182259 |
| Active Moiety | CHEMBL1182259 |
4
Targets
6
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
370.5
MW (Da)
3.62
ALogP
4
HBA
0
HBD
36.9
PSA (Ų)
0.77
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.78
Ki 2 meas. best 5.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| DNA dC->dU-editing enzyme APOBEC-3G CHEMBL1741217 | IC50 | 5.78 | 5.78 | 1660.0 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3A CHEMBL1741179 | IC50 | 5.73 | 5.73 | 1850.0 | 1 |
| Neuronal acetylcholine receptor; alpha4/beta2 CHEMBL1907589 | Ki | 5.0 | 5.0 | 10000.0 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 CHEMBL2492 | Ki | 4.75 | 4.75 | 18000.0 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 CHEMBL2492 | IC50 | 4.68 | 4.68 | 21000.0 | 1 |
| Neuronal acetylcholine receptor; alpha4/beta2 CHEMBL1907589 | IC50 | 4.47 | 4.47 | 34000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| DNA dC->dU-editing enzyme APOBEC-3G | IC50 | = | 1660.0 | nM | 5.78 | PUBCHEM_BIOASSAY: Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitor... | - |
| DNA dC->dU-editing enzyme APOBEC-3A | IC50 | = | 1850.0 | nM | 5.73 | PUBCHEM_BIOASSAY: Dose Response confirmation of small molecule APOBEC3A DNA Deam... | - |
| Neuronal acetylcholine receptor; alpha4/beta2 | Ki | = | 10000.0 | nM | 5.0 | Displacement of [3H]cytisine from human alpha-4-beta-2 nAChR expressed in SH-EP1... | 17391965 |
| Neuronal acetylcholine receptor subunit alpha-7 | Ki | = | 18000.0 | nM | 4.75 | Displacement of [125I]alpha-bungarotoxin from human alpha-7 nAChR expressed in S... | 17391965 |
| Neuronal acetylcholine receptor subunit alpha-7 | IC50 | = | 21000.0 | nM | 4.68 | Displacement of [125I]alpha-bungarotoxin from human alpha-7 nAChR expressed in S... | 17391965 |
| Neuronal acetylcholine receptor; alpha4/beta2 | IC50 | = | 34000.0 | nM | 4.47 | Displacement of [3H]cytisine from human alpha-4-beta-2 nAChR expressed in SH-EP1... | 17391965 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17391965 | 10.1016/j.bmc.2007.03.023 | Neuronal acetylcholine receptor subunit alpha-7 | 2 |
| 17391965 | 10.1016/j.bmc.2007.03.023 | Neuronal acetylcholine receptor; alpha4/beta2 | 2 |
Data from ChEMBL 36 via Core Engine