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Compound Detail

CHEMBL2260984

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CCOC(=O)S(=O)(=O)Oc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)c[nH]c12

Basic Information

ChEMBL ID CHEMBL2260984
Phase Preclinical
Structure Type MOL
InChI Key CMGAUMQGUMDUGO-VGSWGCGISA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

607.7
MW (Da)
4.15
ALogP
10
HBA
4
HBD
163.9
PSA (Ų)
0.14
QED
1
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H29N3O8S3
MW 607.73
Aromatic Rings 4
Heavy Atoms 40
NP-Likeness -1.06

Activity Summary

EC50 3 meas. best 8.92

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 8.92 8.92 1.2 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 8.14 8.14 7.2 1
Beta-2 adrenergic receptor
CHEMBL210
EC50 7.24 7.24 58.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21170122 10.1007/s00044-009-9257-x Beta-3 adrenergic receptor 1
21170122 10.1007/s00044-009-9257-x Beta-1 adrenergic receptor 1
21170122 10.1007/s00044-009-9257-x Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine