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Compound Detail

CHEMBL2260988

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COc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(NS(=O)(=O)c4cccs4)c3)cn(Cc3ccccc3)c12

Basic Information

ChEMBL ID CHEMBL2260988
Phase Preclinical
Structure Type MOL
InChI Key WDBAGEJAANHUNF-DFHRPNOPSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

575.8
MW (Da)
5.81
ALogP
7
HBA
3
HBD
92.6
PSA (Ų)
0.17
QED
2
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H33N3O4S2
MW 575.76
Aromatic Rings 5
Heavy Atoms 40
NP-Likeness -1.22

Activity Summary

EC50 3 meas. best 8.36

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 8.36 8.36 4.4 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 7.66 7.66 22.0 1
Beta-2 adrenergic receptor
CHEMBL210
EC50 7.5 7.5 32.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21170122 10.1007/s00044-009-9257-x Beta-3 adrenergic receptor 1
21170122 10.1007/s00044-009-9257-x Beta-1 adrenergic receptor 1
21170122 10.1007/s00044-009-9257-x Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine