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Compound Detail

CHEMBL2311153

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COc1cc(CCN2CCN(CCCc3ccccc3)CC2)ccc1O[11CH3]

Basic Information

ChEMBL ID CHEMBL2311153
Phase Preclinical
Structure Type MOL
InChI Key UVSWWUWQVAQPJR-BJUDXGSMSA-N
Parent Compound CHEMBL408867
Active Moiety CHEMBL408867
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

368.5
MW (Da)
3.50
ALogP
4
HBA
0
HBD
24.9
PSA (Ų)
0.68
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H32N2O2
MW 367.52
Aromatic Rings 2
Heavy Atoms 27
NP-Likeness -0.55

Activity Summary

Ki 4 meas. best 8.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
CHEMBL4931
Ki 8.77 8.7667 1.7 3
Sigma non-opioid intracellular receptor 1
CHEMBL287
Ki 8.36 8.36 4.4 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23566245 10.1021/jm301734g Nucleic Acid 6
23566245 10.1021/jm301734g Brain 2
21481592 10.1016/j.bmc.2011.03.037 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1
22136765 10.1016/j.bmc.2011.11.002 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1
22853801 10.1021/jm300371c 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1
23566245 10.1021/jm301734g Unchecked 1
23566245 10.1021/jm301734g Sigma non-opioid intracellular receptor 1 1

Data from ChEMBL 36 via Core Engine