Compound Detail
CHEMBL2321968
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Basic Information
| ChEMBL ID | CHEMBL2321968 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XTBZMVZULARPGA-YPKPFQOOSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
306.3
MW (Da)
2.36
ALogP
4
HBA
3
HBD
95.5
PSA (Ų)
0.70
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 5.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen synthase kinase 3 beta CHEMBL1909485 | IC50 | 5.96 | 5.96 | 1100.0 | 1 |
| Casein kinase I isoform alpha CHEMBL1781858 | IC50 | 5.85 | 5.85 | 1400.0 | 1 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 2 CHEMBL4376 | IC50 | 5.75 | 5.75 | 1800.0 | 1 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A CHEMBL5508 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
| Cyclin-dependent kinase 5 CHEMBL4036 | IC50 | 5.47 | 5.47 | 3400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen synthase kinase 3 beta | IC50 | = | 1100.0 | nM | 5.96 | Inhibition of porcine brain GSK3beta using YRRAAVPPSPSLSRHSSPHQSpEDEEE as substr... | 23336033 |
| Casein kinase I isoform alpha | IC50 | = | 1400.0 | nM | 5.85 | Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate | 23336033 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 2 | IC50 | = | 1800.0 | nM | 5.75 | Inhibition of human recombinant GST-fused DYRK2 expressed in Escherichia coli us... | 23336033 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli usi... | 23336033 |
| Cyclin-dependent kinase 5 | IC50 | = | 3400.0 | nM | 5.47 | Inhibition of human recombinant CDK5 | 23336033 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23336033 | 10.1021/ml300207a | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | 1 |
| 23336033 | 10.1021/ml300207a | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 1 |
| 23336033 | 10.1021/ml300207a | Casein kinase I isoform alpha | 1 |
| 23336033 | 10.1021/ml300207a | Glycogen synthase kinase 3 beta | 1 |
| 23336033 | 10.1021/ml300207a | Cyclin-dependent kinase 5 | 1 |
| 28557430 | 10.1021/acs.jmedchem.7b00324 | No relevant target | 1 |
| 28557430 | 10.1021/acs.jmedchem.7b00324 | MCF7 | 1 |
Data from ChEMBL 36 via Core Engine