Compound Detail
CHEMBL2326011
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Basic Information
| ChEMBL ID | CHEMBL2326011 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PXRPXQKBRGMQJJ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
398.5
MW (Da)
3.00
ALogP
6
HBA
2
HBD
79.0
PSA (Ų)
0.69
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C theta type CHEMBL3920 | Ki | 8.0 | 8.0 | 10.0 | 1 |
| Protein kinase C delta type CHEMBL2996 | Ki | 6.32 | 6.32 | 480.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C theta type | Ki | = | 10.0 | nM | 8.0 | Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQ... | 23398373 |
| Protein kinase C delta type | Ki | = | 480.0 | nM | 6.32 | Inhibition of PKC delta (unknown origin) using ERMRPRKRQGSVRRRV as substrate aft... | 23398373 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23398373 | 10.1021/jm301465a | Unchecked | 1 |
| 23398373 | 10.1021/jm301465a | Protein kinase C delta type | 1 |
| 23398373 | 10.1021/jm301465a | Protein kinase C theta type | 1 |
Data from ChEMBL 36 via Core Engine