Compound Detail
CHEMBL2337367
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Basic Information
| ChEMBL ID | CHEMBL2337367 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BCUHRSRTCIJILL-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
393.9
MW (Da)
5.49
ALogP
4
HBA
3
HBD
82.7
PSA (Ų)
0.43
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 4.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 4.15 | 4.15 | 70600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta | IC50 | = | 70600.0 | nM | 4.15 | Inhibition of PDGFRbeta in human SF539 cells assessed as inhibition of PDGFR-BB-... | 23434139 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23434139 | 10.1016/j.bmc.2013.01.040 | A-431 | 1 |
| 23434139 | 10.1016/j.bmc.2013.01.040 | Platelet-derived growth factor receptor beta | 1 |
| 23434139 | 10.1016/j.bmc.2013.01.040 | Epidermal growth factor receptor | 1 |
| 23434139 | 10.1016/j.bmc.2013.01.040 | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine