Compound Detail
CHEMBL2347594
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Basic Information
| ChEMBL ID | CHEMBL2347594 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XGOGJKVSHQHTDQ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
358.4
MW (Da)
3.31
ALogP
9
HBA
3
HBD
126.1
PSA (Ų)
0.47
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| CDK9/cyclin T1 CHEMBL2111389 | Ki | 6.03 | 6.03 | 932.0 | 1 |
| Cyclin-dependent kinase 1/cyclin B1 CHEMBL1907602 | Ki | 5.85 | 5.85 | 1424.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| CDK9/cyclin T1 | Ki | = | 932.0 | nM | 6.03 | Inhibition of human recombinant His6 tagged CDK9/CyclinT1 expressed in Sf21 inse... | 23301767 |
| Cyclin-dependent kinase 1/cyclin B1 | Ki | = | 1424.0 | nM | 5.85 | Inhibition of human recombinant His6 tagged CDK1/Cyclin B expressed in Sf21 inse... | 23301767 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23301767 | 10.1021/jm301475f | HCT-116 | 1 |
| 23301767 | 10.1021/jm301475f | Cyclin-dependent kinase 7/ cyclin H | 1 |
| 23301767 | 10.1021/jm301475f | Cyclin-dependent kinase 2/cyclin A | 1 |
| 23301767 | 10.1021/jm301475f | Cyclin-dependent kinase 1/cyclin B1 | 1 |
| 23301767 | 10.1021/jm301475f | CDK9/cyclin T1 | 1 |
Data from ChEMBL 36 via Core Engine