Compound Detail
CHEMBL2369752
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C[C@H](O)[C@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](Cc2cccnc2)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(Cl)cc2)CSSC[C@H](C(=O)N[C@@H](Cc2ccc3ccccc3c2)C(N)=O)NC1=O
Basic Information
| ChEMBL ID | CHEMBL2369752 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | ZGBQWTWDBMDEHO-LDXNCXQMSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
1177.8
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 7.29
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 2 CHEMBL1804 | Ki | 7.29 | 7.29 | 51.8 | 1 |
| Somatostatin receptor type 5 CHEMBL1792 | Ki | 7.03 | 7.03 | 93.0 | 1 |
| Somatostatin receptor type 3 CHEMBL2028 | Ki | 6.41 | 6.41 | 390.0 | 1 |
| Somatostatin receptor type 4 CHEMBL1853 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
| Somatostatin receptor type 1 CHEMBL1917 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 2 | Ki | = | 51.8 | nM | 7.29 | Ability to displace [125 I]labelled Tyr11-somatostatin from human hsst-2 recepto... | 11312929 |
| Somatostatin receptor type 5 | Ki | = | 93.0 | nM | 7.03 | Ability to displace [125 I]labelled Tyr11-somatostatin from human hsst-5 recepto... | 11312929 |
| Somatostatin receptor type 3 | Ki | = | 390.0 | nM | 6.41 | Ability to displace [125 I]labelled Tyr11-somatostatin from human hsst-3 recepto... | 11312929 |
| Somatostatin receptor type 1 | Ki | = | 1000.0 | nM | 6.0 | Ability to displace [125 I]labelled Tyr11-somatostatin from human hsst-1 recepto... | 11312929 |
| Somatostatin receptor type 4 | Ki | = | 1000.0 | nM | 6.0 | Ability to displace [125 I]labelled Tyr11-somatostatin from human hsst-4 recepto... | 11312929 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11312929 | 10.1021/jm0005048 | Somatostatin receptor type 1 | 1 |
| 11312929 | 10.1021/jm0005048 | Somatostatin receptor type 2 | 1 |
| 11312929 | 10.1021/jm0005048 | Somatostatin receptor type 3 | 1 |
| 11312929 | 10.1021/jm0005048 | Somatostatin receptor type 4 | 1 |
| 11312929 | 10.1021/jm0005048 | Somatostatin receptor type 5 | 1 |
| 11312929 | 10.1021/jm0005048 | Somatostatin receptor | 1 |
Data from ChEMBL 36 via Core Engine