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Assay Detail

CHEMBL872701

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Ability to displace [125 I]labelled Tyr11-somatostatin from human hsst-3 receptor expressed on CHO cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Somatostatin receptor type 3 (CHEMBL2028)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Highly potent and subtype selective ligands derived by N-methyl scan of a somatostatin antagonist.
Rajeswaran WG, Hocart SJ, Murphy WA, Taylor JE, Coy DH.
J Med Chem (2001) 44 : 1305 -1311
PubMed 11312929 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 6.94 8.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1794035 1 8.92
CHEMBL442494 1 8.89
CHEMBL2369760 1 7.63
CHEMBL2369749 1 7.42
CHEMBL2371893 1 7.40
CHEMBL2369755 1 7.18
CHEMBL2369734 1 7.16
CHEMBL2369735 1 7.04
CHEMBL2311098 1 6.94
CHEMBL2369754 1 6.85
CHEMBL2369758 1 6.83
CHEMBL2369753 1 6.50
CHEMBL2369750 1 6.48
CHEMBL2369752 1 6.41
CHEMBL2369756 1 6.35
CHEMBL2369757 1 6.27
CHEMBL2369751 1 6.24
CHEMBL2369761 1 6.23
CHEMBL2369759 1 6.00
CHEMBL2369733 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1794035 Ki = 1.2 nM 8.92
CHEMBL442494 Ki = 1.3 nM 8.89
CHEMBL2369760 Ki = 23.6 nM 7.63
CHEMBL2369749 Ki = 38.2 nM 7.42
CHEMBL2371893 Ki = 40.2 nM 7.40
CHEMBL2369755 Ki = 66.0 nM 7.18
CHEMBL2369734 Ki = 68.7 nM 7.16
CHEMBL2369735 Ki = 91.4 nM 7.04
CHEMBL2311098 Ki = 115.1 nM 6.94
CHEMBL2369754 Ki = 140.0 nM 6.85
CHEMBL2369758 Ki = 148.0 nM 6.83
CHEMBL2369753 Ki = 315.0 nM 6.50
CHEMBL2369750 Ki = 330.0 nM 6.48
CHEMBL2369752 Ki = 390.0 nM 6.41
CHEMBL2369756 Ki = 450.0 nM 6.35
CHEMBL2369757 Ki = 537.0 nM 6.27
CHEMBL2369751 Ki = 576.0 nM 6.24
CHEMBL2369761 Ki = 584.0 nM 6.23
CHEMBL2369759 Ki = 1000.0 nM 6.00
CHEMBL2369733 Ki = 1000.0 nM 6.00