Compound Detail
CHEMBL2369761
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CNC(=O)[C@@H](NC(=O)[C@@H]1CSSC[C@@H](N(C)C(=O)C(N)Cc2ccc(Cl)cc2)C(=O)N[C@@H](Cc2cccnc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]([C@H](C)O)C(=O)N1)C(c1ccccc1)c1ccccc1
Basic Information
| ChEMBL ID | CHEMBL2369761 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YAYWDFOWCWBWEH-OYYDMNGWSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
1217.9
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 6.93
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 2 CHEMBL1804 | Ki | 6.93 | 6.93 | 117.0 | 1 |
| Somatostatin receptor type 3 CHEMBL2028 | Ki | 6.23 | 6.23 | 584.0 | 1 |
| Somatostatin receptor type 5 CHEMBL1792 | Ki | 6.12 | 6.12 | 766.0 | 1 |
| Somatostatin receptor type 4 CHEMBL1853 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
| Somatostatin receptor type 1 CHEMBL1917 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 2 | Ki | = | 117.0 | nM | 6.93 | Ability to displace [125 I]labelled Tyr11-somatostatin from human hsst-2 recepto... | 11312929 |
| Somatostatin receptor type 3 | Ki | = | 584.0 | nM | 6.23 | Ability to displace [125 I]labelled Tyr11-somatostatin from human hsst-3 recepto... | 11312929 |
| Somatostatin receptor type 5 | Ki | = | 766.0 | nM | 6.12 | Ability to displace [125 I]labelled Tyr11-somatostatin from human hsst-5 recepto... | 11312929 |
| Somatostatin receptor type 1 | Ki | = | 1000.0 | nM | 6.0 | Ability to displace [125 I]labelled Tyr11-somatostatin from human hsst-1 recepto... | 11312929 |
| Somatostatin receptor type 4 | Ki | = | 1000.0 | nM | 6.0 | Ability to displace [125 I]labelled Tyr11-somatostatin from human hsst-4 recepto... | 11312929 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11312929 | 10.1021/jm0005048 | Somatostatin receptor type 1 | 1 |
| 11312929 | 10.1021/jm0005048 | Somatostatin receptor type 2 | 1 |
| 11312929 | 10.1021/jm0005048 | Somatostatin receptor type 3 | 1 |
| 11312929 | 10.1021/jm0005048 | Somatostatin receptor type 4 | 1 |
| 11312929 | 10.1021/jm0005048 | Somatostatin receptor type 5 | 1 |
| 11312929 | 10.1021/jm0005048 | Somatostatin receptor | 1 |
Data from ChEMBL 36 via Core Engine