Compound Detail
CHEMBL2376217
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Basic Information
| ChEMBL ID | CHEMBL2376217 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GIHRXZIOYXHBBA-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
323.4
MW (Da)
2.97
ALogP
6
HBA
0
HBD
73.1
PSA (Ų)
0.74
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL3229 | IC50 | 7.62 | 7.62 | 24.0 | 1 |
| Monoglyceride lipase CHEMBL4191 | IC50 | 7.17 | 7.17 | 67.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 24.0 | nM | 7.62 | Inhibition of FAAH in Sprague-Dawley rat brain microsomes assessed as N-(2-hydro... | 23455058 |
| Monoglyceride lipase | IC50 | = | 67.0 | nM | 7.17 | Inhibition of human recombinant MAGL-mediated 1,3-dihydroxypropan-1-yl 4-pyren-1... | 23455058 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23455058 | 10.1016/j.ejmech.2013.01.050 | Fatty-acid amide hydrolase 1 | 1 |
| 23455058 | 10.1016/j.ejmech.2013.01.050 | Monoglyceride lipase | 1 |
Data from ChEMBL 36 via Core Engine