Compound Detail
CHEMBL2386007
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Basic Information
| ChEMBL ID | CHEMBL2386007 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NFJFUDGBWGXTHS-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
227.3
MW (Da)
2.75
ALogP
2
HBA
1
HBD
35.2
PSA (Ų)
0.85
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 5.26 | 5.26 | 5480.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | IC50 | = | 5480.0 | nM | 5.26 | Displacement of [3H]MK-801 from NMDA receptor in Wistar rat brain membranes by s... | 26296478 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26296478 | 10.1016/j.bmcl.2015.08.017 | Glutamate NMDA receptor | 15 |
| 23602525 | 10.1016/j.bmc.2013.03.037 | ORAI 1/2/3 | 2 |
| 23602525 | 10.1016/j.bmc.2013.03.037 | Transient receptor potential cation channel subfamily V member 6 | 2 |
Data from ChEMBL 36 via Core Engine