Assay Detail
Binding
CHEMBL3619813
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]MK-801 from NMDA receptor in Wistar rat brain membranes by scintillation counting analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Differential influence of 7 cations on 16 non-competitive NMDA receptor blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.71 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275528 | PHENCYCLIDINE | 2.0 | 1 | 6.96 |
| CHEMBL293092 | — | — | 1 | 6.96 |
| CHEMBL269032 | — | — | 1 | 6.46 |
| CHEMBL229102 | — | — | 1 | 6.37 |
| CHEMBL395091 | ESKETAMINE | 4.0 | 1 | 6.19 |
| CHEMBL447983 | — | — | 1 | 6.11 |
| CHEMBL807 | MEMANTINE | 4.0 | 1 | 5.96 |
| CHEMBL52440 | DEXTROMETHORPHAN | 4.0 | 1 | 5.88 |
| CHEMBL467505 | — | — | 1 | 5.67 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 5.52 |
| CHEMBL2386007 | — | — | 1 | 5.26 |
| CHEMBL824 | NOR2-CHLORPROMAZINE | — | 1 | 5.24 |
| CHEMBL102740 | ARCAINE | — | 1 | 5.19 |
| CHEMBL3618118 | — | — | 1 | 5.13 |
| CHEMBL69590 | — | — | 1 | 5.08 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 4.68 |
| CHEMBL21731 | MAPROTILINE | 4.0 | 1 | 4.42 |
| CHEMBL55830 | TRYPTOPHAN METHYL ESTER | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275528 | PHENCYCLIDINE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL293092 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL269032 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL229102 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL395091 | ESKETAMINE | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL447983 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL807 | MEMANTINE | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL52440 | DEXTROMETHORPHAN | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL467505 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL2386007 | — | IC50 | = | 5480.0 | nM | 5.26 |
| CHEMBL824 | NOR2-CHLORPROMAZINE | IC50 | = | 5790.0 | nM | 5.24 |
| CHEMBL102740 | ARCAINE | IC50 | = | 6390.0 | nM | 5.19 |
| CHEMBL3618118 | — | IC50 | = | 7440.0 | nM | 5.13 |
| CHEMBL69590 | — | IC50 | = | 8390.0 | nM | 5.08 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL21731 | MAPROTILINE | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL55830 | TRYPTOPHAN METHYL ESTER | IC50 | = | 169000.0 | nM | - |