Compound Detail
CHEMBL824
NOR2-CHLORPROMAZINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL824 |
| Name | NOR2-CHLORPROMAZINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZTQZBABFEUDZFE-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
290.8
MW (Da)
4.29
ALogP
3
HBA
1
HBD
29.3
PSA (Ų)
0.91
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Pleiotropic ABC efflux transporter of multiple drugs CHEMBL1697658 | IC50 | 5.5 | 5.5 | 3200.0 | 1 |
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 5.24 | 5.24 | 5790.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Pleiotropic ABC efflux transporter of multiple drugs | IC50 | = | 3200.0 | nM | 5.5 | Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae ... | 19188399 |
| Glutamate NMDA receptor | IC50 | = | 5790.0 | nM | 5.24 | Displacement of [3H]MK-801 from NMDA receptor in Wistar rat brain membranes by s... | 26296478 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26296478 | 10.1016/j.bmcl.2015.08.017 | Glutamate NMDA receptor | 15 |
| 9457238 | 10.1021/jm960814j | Mus musculus | 3 |
| 19188399 | 10.1128/aac.00956-08 | Pleiotropic ABC efflux transporter of multiple drugs | 2 |
| 9457238 | 10.1021/jm960814j | Trypanothione reductase | 1 |
| 9457238 | 10.1021/jm960814j | Glutathione reductase, mitochondrial | 1 |
| 9599232 | 10.1021/jm970786k | MCF7-DOX | 1 |
| 19188399 | 10.1128/aac.00956-08 | Unchecked | 1 |
| 19188399 | 10.1128/aac.00956-08 | Snq2p | 1 |
Data from ChEMBL 36 via Core Engine