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Compound Detail

CHEMBL447983

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C[C@](N)(Cc1ccccc1)c1ccccc1

Basic Information

ChEMBL ID CHEMBL447983
Phase Preclinical
Structure Type MOL
InChI Key JINQHBRSXWQJAZ-HNNXBMFYSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

211.3
MW (Da)
3.10
ALogP
1
HBA
1
HBD
26.0
PSA (Ų)
0.83
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H17N
MW 211.31
Aromatic Rings 2
Heavy Atoms 16
NP-Likeness -0.02

Activity Summary

IC50 1 meas. best 6.11
Ki 1 meas. best 6.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Glutamate NMDA receptor
CHEMBL1907608
IC50 6.11 6.11 780.0 1
Glutamate NMDA receptor
CHEMBL1907608
Ki 6.1 6.1 790.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
26296478 10.1016/j.bmcl.2015.08.017 Glutamate NMDA receptor 15
19345586 10.1016/j.bmc.2009.03.025 Glutamate NMDA receptor 2
- 10.6019/CHEMBL3301361 ADMET 1
- 10.6019/CHEMBL3301361 No relevant target 1

Data from ChEMBL 36 via Core Engine