Assay Detail
Binding
CHEMBL978910
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]MK801 from NMDA receptor in rat brain neuronal membrane
39
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 39 | 5.51 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | 2.0 | 2 | 8.05 |
| CHEMBL467085 | — | — | 1 | 6.92 |
| CHEMBL275528 | PHENCYCLIDINE | 2.0 | 1 | 6.57 |
| CHEMBL449151 | — | — | 1 | 6.16 |
| CHEMBL447983 | — | — | 1 | 6.10 |
| CHEMBL395091 | ESKETAMINE | 4.0 | 1 | 6.02 |
| CHEMBL1638 | — | — | 1 | 5.77 |
| CHEMBL1908323 | LEVOMETHORPHAN | 2.0 | 1 | 5.47 |
| CHEMBL467126 | — | — | 1 | 5.38 |
| CHEMBL381340 | — | — | 1 | 5.38 |
| CHEMBL52440 | DEXTROMETHORPHAN | 4.0 | 1 | 5.34 |
| CHEMBL466089 | — | — | 1 | 5.28 |
| CHEMBL467505 | — | — | 1 | 5.25 |
| CHEMBL451286 | — | — | 1 | 5.09 |
| CHEMBL467084 | LANICEMINE | 2.0 | 1 | 4.85 |
| CHEMBL461517 | — | — | 1 | 4.80 |
| CHEMBL467307 | — | — | 1 | 4.60 |
| CHEMBL467308 | — | — | 1 | 4.29 |
| CHEMBL467504 | — | — | 1 | 4.26 |
| CHEMBL467503 | AMINODIPHENYLMETHANE | — | 1 | 4.19 |
| CHEMBL466285 | — | — | 1 | 4.08 |
| CHEMBL446225 | — | — | 1 | - |
| CHEMBL19969 | — | — | 1 | - |
| CHEMBL442934 | — | — | 1 | - |
| CHEMBL612 | DEXTROAMPHETAMINE | 4.0 | 1 | - |
| CHEMBL257990 | (+)-TRANYLCYPROMINE | — | 1 | - |
| CHEMBL467523 | — | — | 1 | - |
| CHEMBL467528 | — | — | 1 | - |
| CHEMBL53697 | — | — | 1 | - |
| CHEMBL10780 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL284237 | DIZOCILPINE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL467085 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL275528 | PHENCYCLIDINE | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL449151 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL447983 | — | Ki | = | 790.0 | nM | 6.10 |
| CHEMBL395091 | ESKETAMINE | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL1638 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL1908323 | LEVOMETHORPHAN | Ki | = | 3360.0 | nM | 5.47 |
| CHEMBL467126 | — | Ki | = | 4180.0 | nM | 5.38 |
| CHEMBL381340 | — | Ki | = | 4120.0 | nM | 5.38 |
| CHEMBL52440 | DEXTROMETHORPHAN | Ki | = | 4540.0 | nM | 5.34 |
| CHEMBL466089 | — | Ki | = | 5250.0 | nM | 5.28 |
| CHEMBL467505 | — | Ki | = | 5680.0 | nM | 5.25 |
| CHEMBL451286 | — | Ki | = | 8080.0 | nM | 5.09 |
| CHEMBL467084 | LANICEMINE | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL461517 | — | Ki | = | 15700.0 | nM | 4.80 |
| CHEMBL467307 | — | Ki | = | 25100.0 | nM | 4.60 |
| CHEMBL467308 | — | Ki | = | 51000.0 | nM | 4.29 |
| CHEMBL467504 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL467503 | AMINODIPHENYLMETHANE | Ki | = | 64000.0 | nM | 4.19 |
| CHEMBL466285 | — | Ki | = | 84000.0 | nM | 4.08 |
| CHEMBL510603 | — | Ki | = | 271000.0 | nM | - |
| CHEMBL522 | BENZYLAMINE | Ki | = | 1063000.0 | nM | - |
| CHEMBL610 | PHENETHYLAMINE | Ki | = | 753000.0 | nM | - |
| CHEMBL282700 | — | Ki | = | 622000.0 | nM | - |
| CHEMBL19393 | LEVAMFETAMINE | Ki | = | 625000.0 | nM | - |
| CHEMBL3989843 | TRANYLCYPROMINE | Ki | = | 544000.0 | nM | - |
| CHEMBL502179 | — | Ki | = | 1372000.0 | nM | - |
| CHEMBL51969 | PHENYLALANINE METHYL ESTER | Ki | = | 701000.0 | nM | - |
| CHEMBL10780 | — | Ki | = | 145000.0 | nM | - |
| CHEMBL53697 | — | Ki | = | 855000.0 | nM | - |
| CHEMBL467528 | — | Ki | - | — | - | |
| CHEMBL467523 | — | Ki | = | 1978000.0 | nM | - |
| CHEMBL257990 | (+)-TRANYLCYPROMINE | Ki | = | 269000.0 | nM | - |
| CHEMBL612 | DEXTROAMPHETAMINE | Ki | = | 300000.0 | nM | - |
| CHEMBL19969 | — | Ki | = | 659000.0 | nM | - |
| CHEMBL442934 | — | Ki | = | 142000.0 | nM | - |
| CHEMBL446225 | — | Ki | = | 138000.0 | nM | - |