Compound Detail
CHEMBL467084
LANICEMINE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL467084 |
| Name | LANICEMINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | FWUQWDCOOWEXRY-ZDUSSCGKSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
5
Known Names
2
Indications
1
Mechanisms
Molecular Properties
198.3
MW (Da)
2.32
ALogP
2
HBA
1
HBD
38.9
PSA (Ų)
0.82
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Glutamate [NMDA] receptor blocker | BLOCKER | Glutamate [NMDA] receptor | ✓ | ✓ |
Indications
Depressive Disorder Depressive Disorder, Major
Activity Summary
Ki 2 meas. best 6.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate [NMDA] receptor CHEMBL2094124 | Ki | 6.25 | 6.25 | 560.0 | 1 |
| Glutamate NMDA receptor CHEMBL1907608 | Ki | 4.85 | 4.85 | 14000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate [NMDA] receptor | Ki | = | 560.0 | nM | 6.25 | Binding affinity to NMDAR (unknown origin) | 32248004 |
| Glutamate NMDA receptor | Ki | = | 14000.0 | nM | 4.85 | Displacement of [3H]MK801 from NMDA receptor in rat brain neuronal membrane | 19345586 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL3988442 | Unchecked | 3 |
| 19345586 | 10.1016/j.bmc.2009.03.025 | Glutamate NMDA receptor | 2 |
| - | 10.6019/CHEMBL4513160 | Pseudomonas aeruginosa | 2 |
| - | 10.6019/CHEMBL4513160 | Acinetobacter baumannii | 1 |
| 32248004 | 10.1016/j.ejmech.2020.112242 | Glutamate [NMDA] receptor | 1 |
Data from ChEMBL 36 via Core Engine