Compound Detail

CHEMBL2386970

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Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C5CN(CCO)C5)c4)cc2OCC3)n(C(C)C)n1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL2386970
Phase	Preclinical
Structure Type	MOL
InChI Key	XUJGAWJCUSXSNC-UHFFFAOYSA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

474.6

MW (Da)

2.80

ALogP

HBA

HBD

99.0

PSA (Å²)

0.46

QED

Ro5 Violations

Rot. Bonds

First in Class Prodrug

IC50 2 meas. best 8.85

Ki 1 meas. best 9.96

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005	Ki	9.96	9.96	0.1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005	IC50	8.85	8.85	1.4	1
NON-PROTEIN TARGET CHEMBL3879801	IC50	6.92	6.92	120.0	1

Parameter	Value	Units	Species
CL	58.0	mL.min-1.kg-1	Mus musculus

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Ki	=	0.11	nM	9.96	Inhibition of PI3Kalpha (unknown origin) assessed as 3,4,5-inositoltriphosphate ...	23662903
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	IC50	=	1.4	nM	8.85	Inhibition of PI3Kalpha in human MCF7-neo/Her2 cells assessed as reduction of AK...	23662903
NON-PROTEIN TARGET	IC50	=	120.0	nM	6.92	Cytotoxicity against human MCF7-neo/Her2 cells after 3 to 4 days by CellTitre-Gl...	23662903

PubMed	DOI	Target Context	# Activities
23662903	10.1021/jm4003632	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	2
23662903	10.1021/jm4003632	No relevant target	1
23662903	10.1021/jm4003632	Liver	1
23662903	10.1021/jm4003632	NON-PROTEIN TARGET	1
23662903	10.1021/jm4003632	Unchecked	1

Data from ChEMBL 36 via Core Engine