Compound Detail
CHEMBL2387085
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Basic Information
| ChEMBL ID | CHEMBL2387085 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OSJIJSHVTFOMRV-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
1
PK Parameters
5
Publications
0
Known Names
Molecular Properties
391.4
MW (Da)
1.90
ALogP
9
HBA
1
HBD
95.8
PSA (Ų)
0.57
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.85
Ki 1 meas. best 8.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | Ki | 8.55 | 8.55 | 2.8 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 5.85 | 5.85 | 1400.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 100.0 | mL.min-1.kg-1 | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Ki | = | 2.8 | nM | 8.55 | Inhibition of PI3Kalpha (unknown origin) assessed as 3,4,5-inositoltriphosphate ... | 23662903 |
| NON-PROTEIN TARGET | IC50 | = | 1400.0 | nM | 5.85 | Cytotoxicity against human MCF7-neo/Her2 cells after 3 to 4 days by CellTitre-Gl... | 23662903 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23662903 | 10.1021/jm4003632 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 2 |
| 23662903 | 10.1021/jm4003632 | No relevant target | 1 |
| 23662903 | 10.1021/jm4003632 | Liver | 1 |
| 23662903 | 10.1021/jm4003632 | NON-PROTEIN TARGET | 1 |
| 23662903 | 10.1021/jm4003632 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine