Compound Detail
CHEMBL2387240
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Basic Information
| ChEMBL ID | CHEMBL2387240 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LAFPJOIXDXNYEH-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
452.5
MW (Da)
4.00
ALogP
7
HBA
1
HBD
88.9
PSA (Ų)
0.44
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A CHEMBL322 | Ki | 6.34 | 6.34 | 452.8 | 1 |
| 5-hydroxytryptamine receptor 1A CHEMBL273 | Ki | 6.29 | 6.29 | 517.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | Ki | = | 452.8 | nM | 6.34 | Displacement of [3H]ketanserin from 5HT2A receptor in rat cerebral cortex after ... | 23675993 |
| 5-hydroxytryptamine receptor 1A | Ki | = | 517.2 | nM | 6.29 | Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat cerebral cortex after 3... | 23675993 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23675993 | 10.1021/jm400408r | 5-hydroxytryptamine receptor 2A | 1 |
| 23675993 | 10.1021/jm400408r | 5-hydroxytryptamine receptor 1A | 1 |
| 23675993 | 10.1021/jm400408r | D(2) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine