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Compound Detail

CHEMBL239208

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C=C(C)C1CCC(C)=C[C@H]1c1c(O)cc(C2(CCCCCC)SCCS2)cc1O

Basic Information

ChEMBL ID CHEMBL239208
Phase Preclinical
Structure Type MOL
InChI Key LVEVTMWLRZZDCH-BPGUCPLFSA-N
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

432.7
MW (Da)
7.72
ALogP
4
HBA
2
HBD
40.5
PSA (Ų)
0.33
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H36O2S2
MW 432.70
Aromatic Rings 1
Heavy Atoms 29
NP-Likeness 1.76

Activity Summary

Ki 5 meas. best 7.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cannabinoid receptor 2
CHEMBL253
Ki 7.3 7.3 50.1 2
Cannabinoid receptor 1
CHEMBL218
Ki 6.87 6.87 134.9 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17521177 10.1021/jm0610705 Cannabinoid receptor 1 2
17521177 10.1021/jm0610705 Cannabinoid receptor 2 2
17980589 10.1016/j.bmcl.2007.10.044 Cannabinoid receptor 1 1

Data from ChEMBL 36 via Core Engine