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Compound Detail

CHEMBL2403420

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CCOc1cc2nc(SCCn3ccnc3)[nH]c2cc1Cl

Basic Information

ChEMBL ID CHEMBL2403420
Phase Preclinical
Structure Type MOL
InChI Key MLKVWTFJVRVJKT-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

322.8
MW (Da)
3.60
ALogP
5
HBA
1
HBD
55.7
PSA (Ų)
0.70
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H15ClN4OS
MW 322.82
Aromatic Rings 3
Heavy Atoms 21
NP-Likeness -2.33

Activity Summary

IC50 3 meas. best 7.33

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
IC50 7.33 7.33 46.5 1
Entamoeba histolytica
CHEMBL612853
IC50 7.21 7.21 62.0 1
Trichomonas vaginalis
CHEMBL612884
IC50 7.0 7.0 99.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23731944 10.1016/j.bmcl.2013.05.012 Entamoeba histolytica 1
23731944 10.1016/j.bmcl.2013.05.012 Giardia intestinalis 1
23731944 10.1016/j.bmcl.2013.05.012 Trichomonas vaginalis 1

Data from ChEMBL 36 via Core Engine