Compound Detail
CHEMBL241972
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Basic Information
| ChEMBL ID | CHEMBL241972 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IDBRULKICVRMNG-VKHMYHEASA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
167.1
MW (Da)
-0.74
ALogP
3
HBA
3
HBD
100.6
PSA (Ų)
0.48
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 5.76
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 8 CHEMBL2718 | EC50 | 5.76 | 5.76 | 1720.0 | 1 |
| Metabotropic glutamate receptor 4 CHEMBL2787 | EC50 | 5.39 | 5.39 | 4050.0 | 1 |
| Metabotropic glutamate receptor 6 CHEMBL3842 | EC50 | 4.56 | 4.56 | 27800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 8 | EC50 | = | 1720.0 | nM | 5.76 | Agonist activity at rat mGluR8 receptor expressed HEK293 cells assessed as effec... | 17722902 |
| Metabotropic glutamate receptor 4 | EC50 | = | 4050.0 | nM | 5.39 | Agonist activity at rat mGluR4 receptor expressed HEK293 cells assessed as effec... | 17722902 |
| Metabotropic glutamate receptor 6 | EC50 | = | 27800.0 | nM | 4.56 | Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effec... | 17722902 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 4 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 6 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 7 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 8 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 1 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 5 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 2 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 3 | 1 |
Data from ChEMBL 36 via Core Engine