Assay Detail
Functional
CHEMBL896248
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effect on inositol phosphate production
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Metabotropic glutamate receptor 6 (CHEMBL3842) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.46 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243925 | — | — | 1 | 6.14 |
| CHEMBL33567 | — | — | 1 | 5.68 |
| CHEMBL241972 | — | — | 1 | 4.56 |
| CHEMBL145114 | PHOSPHINOTHRICIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243925 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL33567 | — | EC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL241972 | — | EC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL145114 | PHOSPHINOTHRICIN | EC50 | > | 500000.0 | nM | - |