Compound Detail
CHEMBL243925
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL243925 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SBYYVZHQFAJJDQ-VKHMYHEASA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
199.2
MW (Da)
-0.92
ALogP
3
HBA
4
HBD
103.8
PSA (Ų)
0.44
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 7.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2787 | EC50 | 7.41 | 7.41 | 39.0 | 1 |
| Metabotropic glutamate receptor 8 CHEMBL2718 | EC50 | 7.27 | 7.27 | 54.0 | 1 |
| Metabotropic glutamate receptor 6 CHEMBL3842 | EC50 | 6.14 | 6.14 | 730.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | EC50 | = | 39.0 | nM | 7.41 | Agonist activity at rat mGluR4 receptor expressed HEK293 cells assessed as effec... | 17722902 |
| Metabotropic glutamate receptor 8 | EC50 | = | 54.0 | nM | 7.27 | Agonist activity at rat mGluR8 receptor expressed HEK293 cells assessed as effec... | 17722902 |
| Metabotropic glutamate receptor 6 | EC50 | = | 730.0 | nM | 6.14 | Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effec... | 17722902 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 4 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 6 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 7 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 8 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 1 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 5 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 2 | 1 |
| 17722902 | 10.1021/jm070400y | Metabotropic glutamate receptor 3 | 1 |
Data from ChEMBL 36 via Core Engine