Compound Detail
CHEMBL242194
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Basic Information
| ChEMBL ID | CHEMBL242194 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BHSMCUUQKNJNBY-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
297.4
MW (Da)
4.18
ALogP
4
HBA
0
HBD
20.5
PSA (Ų)
0.67
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 8.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein CHEMBL2487 | Ki | 8.08 | 8.08 | 8.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Ki | = | 8.3 | nM | 8.08 | Binding affinity to human beta amyloid plaque in alzheimer's disease patient bra... | 17722900 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17722900 | 10.1021/jm0702231 | Amyloid-beta precursor protein | 1 |
Data from ChEMBL 36 via Core Engine