Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL896239

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human beta amyloid plaque in alzheimer's disease patient brain
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amyloid-beta precursor protein (CHEMBL2487)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and structure-affinity relationships of new 4-(6-iodo-H-imidazo[1,2-a]pyridin-2-yl)-N-dimethylbenzeneamine derivatives as ligands for human beta-amyloid plaques.
Cai L, Cuevas J, Temme S, Herman MM, Dagostin C, Widdowson DA, Innis RB, Pike VW.
J Med Chem (2007) 50 : 4746 -4758
PubMed 17722900 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 28 7.31 8.23

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL81260 1 8.23
CHEMBL245208 1 8.13
CHEMBL244757 1 8.12
CHEMBL442269 1 8.09
CHEMBL388460 1 8.08
CHEMBL242194 1 8.08
CHEMBL78012 1 8.05
CHEMBL241967 1 7.89
CHEMBL394553 1 7.62
CHEMBL70894 1 7.51
CHEMBL243492 1 7.42
CHEMBL69671 1 7.39
CHEMBL244995 1 7.06
CHEMBL244747 1 7.06
CHEMBL394626 1 6.83
CHEMBL387998 1 6.75
CHEMBL242410 1 6.74
CHEMBL244994 1 6.41
CHEMBL241986 1 6.19
CHEMBL245210 1 6.18
CHEMBL241985 1 5.74
CHEMBL388227 1 -
CHEMBL242411 1 -
CHEMBL245214 1 -
CHEMBL244996 1 -
CHEMBL241984 1 -
CHEMBL243935 1 -
CHEMBL388228 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL81260 Ki = 5.9 nM 8.23
CHEMBL245208 Ki = 7.4 nM 8.13
CHEMBL244757 Ki = 7.6 nM 8.12
CHEMBL442269 Ki = 8.2 nM 8.09
CHEMBL388460 Ki = 8.3 nM 8.08
CHEMBL242194 Ki = 8.3 nM 8.08
CHEMBL78012 Ki = 8.9 nM 8.05
CHEMBL241967 Ki = 13.0 nM 7.89
CHEMBL394553 Ki = 24.2 nM 7.62
CHEMBL70894 Ki = 31.0 nM 7.51
CHEMBL243492 Ki = 38.5 nM 7.42
CHEMBL69671 Ki = 41.0 nM 7.39
CHEMBL244995 Ki = 88.0 nM 7.06
CHEMBL244747 Ki = 88.0 nM 7.06
CHEMBL394626 Ki = 147.0 nM 6.83
CHEMBL387998 Ki = 177.0 nM 6.75
CHEMBL242410 Ki = 183.0 nM 6.74
CHEMBL244994 Ki = 391.0 nM 6.41
CHEMBL241986 Ki = 645.0 nM 6.19
CHEMBL245210 Ki = 658.0 nM 6.18
CHEMBL241985 Ki = 1840.0 nM 5.74
CHEMBL388227 Ki > 1000.0 nM -
CHEMBL242411 Ki > 180.0 nM -
CHEMBL245214 Ki > 1000.0 nM -
CHEMBL244996 Ki > 1000.0 nM -
CHEMBL241984 Ki > 1000.0 nM -
CHEMBL243935 Ki > 1000.0 nM -
CHEMBL388228 Ki > 1000.0 nM -