Compound Detail
CHEMBL394626
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Basic Information
| ChEMBL ID | CHEMBL394626 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BBZPZIYKRUODAR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
272.7
MW (Da)
3.12
ALogP
4
HBA
0
HBD
33.4
PSA (Ų)
0.72
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 6.83
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein CHEMBL2487 | Ki | 6.83 | 6.83 | 147.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Ki | = | 147.0 | nM | 6.83 | Binding affinity to human beta amyloid plaque in alzheimer's disease patient bra... | 17722900 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17722900 | 10.1021/jm0702231 | Amyloid-beta precursor protein | 1 |
Data from ChEMBL 36 via Core Engine