Compound Detail
CHEMBL2426282
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2426282 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WIISKNAPHJLZGS-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
419.9
MW (Da)
5.16
ALogP
5
HBA
3
HBD
91.9
PSA (Ų)
0.38
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 8.2 | 8.2 | 6.3 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 7.66 | 7.1533 | 22.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 6.3 | nM | 8.2 | Inhibition of human recombinant N-terminal GST-tagged EGFR L858R/T970M double mu... | 23930994 |
| Epidermal growth factor receptor | IC50 | = | 22.0 | nM | 7.66 | Inhibition of EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 ... | 23930994 |
| Epidermal growth factor receptor | IC50 | = | 29.0 | nM | 7.54 | Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human P... | 23930994 |
| Epidermal growth factor receptor | IC50 | = | 550.0 | nM | 6.26 | Inhibition of wild type EGFR phosphorylation in human LoVo cells after 2 hrs by ... | 23930994 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23930994 | 10.1021/jm400822z | Epidermal growth factor receptor | 3 |
| 23930994 | 10.1021/jm400822z | Unchecked | 2 |
| 23930994 | 10.1021/jm400822z | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine