Compound Detail
CHEMBL2435417
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2435417 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LMQFQBUKMWFFNL-GHXNOFRVSA-N |
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
316.4
MW (Da)
4.45
ALogP
4
HBA
0
HBD
44.8
PSA (Ų)
0.61
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 4.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 4.72 | 4.72 | 18900.0 | 1 |
| Leishmania tarentolae CHEMBL612915 | IC50 | 4.67 | 4.67 | 21300.0 | 1 |
| Leishmania donovani CHEMBL367 | IC50 | 4.33 | 4.33 | 46200.0 | 1 |
| Trypanosoma cruzi CHEMBL368 | IC50 | 4.21 | 4.21 | 61400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 18900.0 | nM | 4.72 | Antiprotozoal activity against chloroquine/pyrimethamine-resistant erythrocytic ... | 23968432 |
| Leishmania tarentolae | IC50 | = | 21300.0 | nM | 4.67 | Antiprotozoal activity against promastigote form of Leishmania tarentolae P10 as... | 23968432 |
| Leishmania donovani | IC50 | = | 46200.0 | nM | 4.33 | Antiprotozoal activity against axenic amastigote form of Leishmania donovani MHO... | 23968432 |
| Trypanosoma cruzi | IC50 | = | 61400.0 | nM | 4.21 | Antiprotozoal activity against intracellular amastigote form of Trypanosoma cruz... | 23968432 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23968432 | 10.1021/jm401007p | Unchecked | 3 |
| 23968432 | 10.1021/jm401007p | Leishmania tarentolae | 1 |
| 23968432 | 10.1021/jm401007p | Leishmania donovani | 1 |
| 23968432 | 10.1021/jm401007p | Trypanosoma cruzi | 1 |
| 23968432 | 10.1021/jm401007p | Trypanosoma brucei rhodesiense | 1 |
| 23968432 | 10.1021/jm401007p | Plasmodium falciparum | 1 |
| 23968432 | 10.1021/jm401007p | L6 | 1 |
Data from ChEMBL 36 via Core Engine