Compound Detail
CHEMBL2441936
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Basic Information
| ChEMBL ID | CHEMBL2441936 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YYTYFOFKJXFIMJ-UHFFFAOYSA-N |
| Parent Compound | CHEMBL3040671 |
| Active Moiety | CHEMBL3040671 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
340.9
MW (Da)
2.74
ALogP
4
HBA
2
HBD
42.4
PSA (Ų)
0.47
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL264 | IC50 | 5.9 | 5.9 | 1258.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | IC50 | = | 1258.93 | nM | 5.9 | Antagonist activity at human histamine H3 receptor expressed in CHO cells assess... | 24140447 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24140447 | 10.1016/j.bmcl.2013.09.052 | Histamine H3 receptor | 1 |
Data from ChEMBL 36 via Core Engine