Compound Detail
CHEMBL251670
(R)-GATIFLOXACIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL251670 |
| Name | (R)-GATIFLOXACIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XUBOMFCQGDBHNK-SNVBAGLBSA-N |
1
Targets
4
Activities
1
Assay Types
1
PK Parameters
1
Publications
0
Known Names
Molecular Properties
375.4
MW (Da)
1.98
ALogP
6
HBA
2
HBD
83.8
PSA (Ų)
0.85
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.47 | 6.08 | 340.0 | 4 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| F | 96.0 | % | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 340.0 | nM | 6.47 | PUBCHEM_BIOASSAY: A screen for inhibitors of the PhoP region in Salmonella Typhi... | - |
| Unchecked | IC50 | = | 360.0 | nM | 6.44 | PUBCHEM_BIOASSAY: A small molecule screen for inhibitors of the PhoP region in S... | - |
| Unchecked | IC50 | = | 780.0 | nM | 6.11 | PUBCHEM_BIOASSAY: A Counter Screen to identiry small molecule screen for inhibit... | - |
| Unchecked | IC50 | = | 4980.0 | nM | 5.3 | PUBCHEM_BIOASSAY: A counter screen for small molecule screen for inhibitors of t... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17870541 | 10.1016/j.bmc.2007.08.060 | Homo sapiens | 1 |
Data from ChEMBL 36 via Core Engine