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Compound Detail

CHEMBL251873

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CCn1c(=O)[nH]c2nc(-c3cnn(Cc4ccccc4)c3)[nH]c2c1=O

Basic Information

ChEMBL ID CHEMBL251873
Phase Preclinical
Structure Type MOL
InChI Key PAZHIGAJOKRYPV-UHFFFAOYSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

336.4
MW (Da)
1.34
ALogP
6
HBA
2
HBD
101.4
PSA (Ų)
0.59
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H16N6O2
MW 336.36
Aromatic Rings 4
Heavy Atoms 25
NP-Likeness -1.53

Activity Summary

Ki 4 meas. best 7.43

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2b
CHEMBL255
Ki 7.43 7.43 37.0 1
Adenosine receptor A3
CHEMBL256
Ki 5.82 5.82 1500.0 1
Adenosine receptor A2a
CHEMBL251
Ki 5.42 5.42 3800.0 1
Adenosine receptor A1
CHEMBL226
Ki 5.25 5.25 5600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18226896 10.1016/j.bmcl.2008.01.008 Unchecked 3
18226896 10.1016/j.bmcl.2008.01.008 Adenosine receptor A2b 1
18226896 10.1016/j.bmcl.2008.01.008 Adenosine receptor A1 1
18226896 10.1016/j.bmcl.2008.01.008 Adenosine receptor A2a 1
18226896 10.1016/j.bmcl.2008.01.008 Adenosine receptor A3 1

Data from ChEMBL 36 via Core Engine