Compound Detail
CHEMBL257627
CODEINONE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL257627 |
| Name | CODEINONE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XYYVYLMBEZUESM-CMKMFDCUSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
297.4
MW (Da)
1.71
ALogP
4
HBA
0
HBD
38.8
PSA (Ų)
0.79
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.53
Ki 1 meas. best 6.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mu-type opioid receptor CHEMBL233 | EC50 | 6.53 | 6.53 | 294.0 | 1 |
| Mu-type opioid receptor CHEMBL233 | Ki | 6.34 | 6.34 | 459.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | EC50 | = | 294.0 | nM | 6.53 | Activation of human mu opioid receptor expressed in HEK293a cells co-expressing ... | 17616524 |
| Mu-type opioid receptor | Ki | = | 459.0 | nM | 6.34 | Displacement of [3H]naloxone from human mu poioid receptor expressed in HEK293 c... | 17616524 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17616524 | 10.1074/jbc.m703272200 | Mu-type opioid receptor | 3 |
Data from ChEMBL 36 via Core Engine