Compound Detail
CHEMBL257665
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CN1CCN(c2ccc(Nc3ncc4c(=O)c(C(N)=O)cn(C5CC6CCC5C6)c4n3)cc2)CC1
Basic Information
| ChEMBL ID | CHEMBL257665 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RZUCEFAFHFOZJN-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
473.6
MW (Da)
2.75
ALogP
8
HBA
2
HBD
109.4
PSA (Ų)
0.59
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 7.09 | 7.09 | 81.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 81.0 | nM | 7.09 | Inhibition of ATP-induced CSF1R autophosphorylation | 18342505 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18342505 | 10.1016/j.bmcl.2008.02.070 | Macrophage colony-stimulating factor 1 receptor | 1 |
| 18342505 | 10.1016/j.bmcl.2008.02.070 | Macrophage | 1 |
Data from ChEMBL 36 via Core Engine