Assay Detail
Binding
CHEMBL950218
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Inhibition of ATP-induced CSF1R autophosphorylation
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.29 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256459 | — | — | 1 | 8.52 |
| CHEMBL402852 | — | — | 1 | 8.40 |
| CHEMBL271461 | — | — | 1 | 8.30 |
| CHEMBL255794 | — | — | 1 | 8.15 |
| CHEMBL404188 | — | — | 1 | 8.10 |
| CHEMBL403776 | — | — | 1 | 8.10 |
| CHEMBL257528 | — | — | 1 | 8.10 |
| CHEMBL255584 | — | — | 1 | 8.10 |
| CHEMBL273193 | — | — | 1 | 7.92 |
| CHEMBL414001 | — | — | 1 | 7.89 |
| CHEMBL256893 | — | — | 1 | 7.85 |
| CHEMBL256405 | — | — | 1 | 7.68 |
| CHEMBL256406 | — | — | 1 | 7.66 |
| CHEMBL255182 | — | — | 1 | 7.51 |
| CHEMBL272332 | — | — | 1 | 7.46 |
| CHEMBL272738 | — | — | 1 | 7.25 |
| CHEMBL272117 | — | — | 1 | 7.25 |
| CHEMBL255181 | — | — | 1 | 7.17 |
| CHEMBL257665 | — | — | 1 | 7.09 |
| CHEMBL404909 | — | — | 1 | 7.03 |
| CHEMBL273194 | — | — | 1 | 6.60 |
| CHEMBL271460 | — | — | 1 | 6.55 |
| CHEMBL257664 | — | — | 1 | 6.38 |
| CHEMBL257865 | — | — | 1 | 6.14 |
| CHEMBL257320 | — | — | 1 | 5.96 |
| CHEMBL272560 | — | — | 1 | 5.75 |
| CHEMBL257318 | — | — | 1 | 5.64 |
| CHEMBL272773 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256459 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL402852 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL271461 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL255794 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL404188 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL403776 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL257528 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL255584 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL273193 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL414001 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL256893 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL256405 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL256406 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL255182 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL272332 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL272738 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL272117 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL255181 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL257665 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL404909 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL273194 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL271460 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL257664 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL257865 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL257320 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL272560 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL257318 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL272773 | — | IC50 | = | 3300.0 | nM | 5.48 |