Compound Detail
CHEMBL273194
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CCOC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(N4CCN(C)CC4)cc3)ncc2c1=O
Basic Information
| ChEMBL ID | CHEMBL273194 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XCJIUNJTUIGAPW-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
524.6
MW (Da)
3.94
ALogP
9
HBA
1
HBD
92.6
PSA (Ų)
0.38
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 6.6 | 6.6 | 250.0 | 1 |
| Macrophage CHEMBL612578 | IC50 | 6.33 | 6.33 | 470.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 250.0 | nM | 6.6 | Inhibition of ATP-induced CSF1R autophosphorylation | 18342505 |
| Macrophage | IC50 | = | 470.0 | nM | 6.33 | Inhibition of CSF1-induced proliferation of mouse bone marrow derived macrophage... | 18342505 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18342505 | 10.1016/j.bmcl.2008.02.070 | Macrophage colony-stimulating factor 1 receptor | 1 |
| 18342505 | 10.1016/j.bmcl.2008.02.070 | Macrophage | 1 |
Data from ChEMBL 36 via Core Engine