Assay Detail
Functional
CHEMBL951150
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Inhibition of CSF1-induced proliferation of mouse bone marrow derived macrophages
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.81 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL255794 | — | — | 1 | 8.52 |
| CHEMBL256405 | — | — | 1 | 8.40 |
| CHEMBL271461 | — | — | 1 | 8.40 |
| CHEMBL255584 | — | — | 1 | 8.22 |
| CHEMBL404188 | — | — | 1 | 8.10 |
| CHEMBL403776 | — | — | 1 | 8.05 |
| CHEMBL256893 | — | — | 1 | 7.96 |
| CHEMBL402852 | — | — | 1 | 7.85 |
| CHEMBL414001 | — | — | 1 | 7.80 |
| CHEMBL256459 | — | — | 1 | 7.80 |
| CHEMBL256406 | — | — | 1 | 7.57 |
| CHEMBL257528 | — | — | 1 | 7.29 |
| CHEMBL273193 | — | — | 1 | 7.05 |
| CHEMBL273194 | — | — | 1 | 6.33 |
| CHEMBL257320 | — | — | 1 | - |
| CHEMBL257318 | — | — | 1 | - |
| CHEMBL272560 | — | — | 1 | - |
| CHEMBL272773 | — | — | 1 | - |
| CHEMBL404909 | — | — | 1 | - |
| CHEMBL271460 | — | — | 1 | - |
| CHEMBL257664 | — | — | 1 | - |
| CHEMBL257865 | — | — | 1 | - |
| CHEMBL257665 | — | — | 1 | - |
| CHEMBL272117 | — | — | 1 | - |
| CHEMBL272332 | — | — | 1 | - |
| CHEMBL255181 | — | — | 1 | - |
| CHEMBL255182 | — | — | 1 | - |
| CHEMBL272738 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL255794 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL256405 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL271461 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL255584 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL404188 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL403776 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL256893 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL402852 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL414001 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL256459 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL256406 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL257528 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL273193 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL273194 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL257320 | — | IC50 | - | — | - | |
| CHEMBL257318 | — | IC50 | - | — | - | |
| CHEMBL272560 | — | IC50 | - | — | - | |
| CHEMBL272773 | — | IC50 | - | — | - | |
| CHEMBL404909 | — | IC50 | - | — | - | |
| CHEMBL271460 | — | IC50 | - | — | - | |
| CHEMBL257664 | — | IC50 | - | — | - | |
| CHEMBL257865 | — | IC50 | - | — | - | |
| CHEMBL257665 | — | IC50 | - | — | - | |
| CHEMBL272117 | — | IC50 | - | — | - | |
| CHEMBL272332 | — | IC50 | - | — | - | |
| CHEMBL255181 | — | IC50 | - | — | - | |
| CHEMBL255182 | — | IC50 | - | — | - | |
| CHEMBL272738 | — | IC50 | - | — | - |