Compound Detail
CHEMBL25868
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Basic Information
| ChEMBL ID | CHEMBL25868 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZJLIUARGRQACPP-SYZQJQIISA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
337.2
MW (Da)
0.35
ALogP
7
HBA
4
HBD
147.5
PSA (Ų)
0.30
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| T-24 CHEMBL614774 | IC50 | 6.22 | 6.22 | 600.0 | 1 |
| Ornithine decarboxylase CHEMBL3511 | IC50 | 5.28 | 5.28 | 5200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| T-24 | IC50 | = | 600.0 | nM | 6.22 | The compound was tested for anti proliferative activity against Human T24 bladde... | 1573631 |
| Ornithine decarboxylase | IC50 | = | 5200.0 | nM | 5.28 | Inhibitory activity against Rat liver ornithine decarboxylase (ODC) | 1573631 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1573631 | 10.1021/jm00086a003 | Ornithine decarboxylase | 1 |
| 1573631 | 10.1021/jm00086a003 | T-24 | 1 |
Data from ChEMBL 36 via Core Engine