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Assay Detail

CHEMBL751948

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against Rat liver ornithine decarboxylase (ODC)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Ornithine decarboxylase (CHEMBL3511)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity.
Stanek J, Frei J, Mett H, Schneider P, Regenass U.
J Med Chem (1992) 35 : 1339 -1344
PubMed 1573631 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.11 7.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL27061 1 7.85
CHEMBL26435 1 7.48
CHEMBL281021 1 7.46
CHEMBL26857 1 7.41
CHEMBL284573 1 7.31
CHEMBL15650 1 7.03
CHEMBL282411 1 5.96
CHEMBL26797 1 5.72
CHEMBL26945 1 5.48
CHEMBL25868 1 5.28
CHEMBL26669 1 5.08
CHEMBL26418 1 4.68
CHEMBL27045 1 4.62
CHEMBL26957 1 4.18
CHEMBL287667 1 -
CHEMBL17061 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL27061 IC50 = 14.0 nM 7.85
CHEMBL26435 IC50 = 33.0 nM 7.48
CHEMBL281021 IC50 = 35.0 nM 7.46
CHEMBL26857 IC50 = 39.0 nM 7.41
CHEMBL284573 IC50 = 49.0 nM 7.31
CHEMBL15650 IC50 = 93.0 nM 7.03
CHEMBL282411 IC50 = 1100.0 nM 5.96
CHEMBL26797 IC50 = 1900.0 nM 5.72
CHEMBL26945 IC50 = 3300.0 nM 5.48
CHEMBL25868 IC50 = 5200.0 nM 5.28
CHEMBL26669 IC50 = 8400.0 nM 5.08
CHEMBL26418 IC50 = 21000.0 nM 4.68
CHEMBL27045 IC50 = 24000.0 nM 4.62
CHEMBL26957 IC50 = 66000.0 nM 4.18
CHEMBL287667 IC50 = 670000.0 nM -
CHEMBL17061 IC50 > 50000.0 nM -