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Compound Detail

CHEMBL269668

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CCCCCc1ccc(OP(=O)(NC(C)C(=O)OC)OCC2OC(n3cc(C)c(=O)[nH]c3=O)CC2N=[N+]=[N-])cc1

Basic Information

ChEMBL ID CHEMBL269668
Phase Preclinical
Structure Type MOL
InChI Key CXVAKSZMXQEAIR-UHFFFAOYSA-N
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

578.6
MW (Da)
3.90
ALogP
10
HBA
2
HBD
186.7
PSA (Ų)
0.08
QED
1
Ro5 Violations
14
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H35N6O8P
MW 578.56
Aromatic Rings 2
Heavy Atoms 40
NP-Likeness 0.39

Activity Summary

EC50 5 meas. best 7.29

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
CCRF-CEM
CHEMBL382
EC50 7.29 6.5367 51.0 3
MT4
CHEMBL388
EC50 7.13 7.06 74.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8478904 10.1021/jm00060a013 CCRF-CEM 4
8478904 10.1021/jm00060a013 MT4 3
8478904 10.1021/jm00060a013 NON-PROTEIN TARGET 1
8478904 10.1021/jm00060a013 Unchecked 1

Data from ChEMBL 36 via Core Engine