Assay Detail
Functional
CHEMBL653605
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Antiviral activity in HIV-2 infected CEM cells which are deficient in Thymidine Kinase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.14 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273850 | — | — | 1 | 5.52 |
| CHEMBL9900 | — | — | 1 | 5.52 |
| CHEMBL266159 | — | — | 1 | 5.16 |
| CHEMBL269668 | — | — | 1 | 5.10 |
| CHEMBL268471 | — | — | 1 | 5.06 |
| CHEMBL275504 | — | — | 1 | 5.05 |
| CHEMBL9526 | — | — | 1 | 5.00 |
| CHEMBL2311110 | — | — | 1 | 4.92 |
| CHEMBL9109 | — | — | 1 | 4.89 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
| CHEMBL9681 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273850 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL9900 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL266159 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL269668 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL268471 | — | EC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL275504 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL9526 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2311110 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL9109 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL129 | ZIDOVUDINE | EC50 | > | 100000.0 | nM | - |
| CHEMBL9681 | — | EC50 | > | 100000.0 | nM | - |