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Compound Detail

CHEMBL9109

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COC(=O)C(NP(=O)(OCC1OC(n2cc(C)c(=O)[nH]c2=O)CC1N=[N+]=[N-])Oc1ccccc1)C(C)C

Basic Information

ChEMBL ID CHEMBL9109
Phase Preclinical
Structure Type MOL
InChI Key CLZOJTGAKBJOSI-UHFFFAOYSA-N
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

536.5
MW (Da)
2.80
ALogP
10
HBA
2
HBD
186.7
PSA (Ų)
0.14
QED
1
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H29N6O8P
MW 536.48
Aromatic Rings 2
Heavy Atoms 37
NP-Likeness 0.33

Activity Summary

EC50 5 meas. best 7.06

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
MT4
CHEMBL388
EC50 7.06 7.03 87.0 2
CCRF-CEM
CHEMBL382
EC50 6.85 6.14 140.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8478904 10.1021/jm00060a013 CCRF-CEM 4
8478904 10.1021/jm00060a013 MT4 3
8478904 10.1021/jm00060a013 NON-PROTEIN TARGET 1
8478904 10.1021/jm00060a013 Unchecked 1

Data from ChEMBL 36 via Core Engine