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Compound Detail

CHEMBL273850

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COC(=O)C(C)NP(=O)(OCC1OC(n2cc(C)c(=O)[nH]c2=O)CC1N=[N+]=[N-])Oc1ccc(F)cc1

Basic Information

ChEMBL ID CHEMBL273850
Phase Preclinical
Structure Type MOL
InChI Key JBFRXGUHTHUTBX-UHFFFAOYSA-N
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

526.4
MW (Da)
2.31
ALogP
10
HBA
2
HBD
186.7
PSA (Ų)
0.15
QED
1
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H24FN6O8P
MW 526.42
Aromatic Rings 2
Heavy Atoms 36
NP-Likeness 0.13

Activity Summary

EC50 5 meas. best 7.39

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
MT4
CHEMBL388
EC50 7.39 7.33 41.0 2
CCRF-CEM
CHEMBL382
EC50 7.32 6.6767 48.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8478904 10.1021/jm00060a013 CCRF-CEM 4
8478904 10.1021/jm00060a013 MT4 3
- 10.1016/S0960-894X(00)80395-9 JM1 2
8478904 10.1021/jm00060a013 NON-PROTEIN TARGET 1
8478904 10.1021/jm00060a013 Unchecked 1

Data from ChEMBL 36 via Core Engine