Compound Detail
CHEMBL273975
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL273975 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NQLVJBCUNXDTMF-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
381.4
MW (Da)
3.86
ALogP
3
HBA
2
HBD
85.1
PSA (Ų)
0.55
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuromedin-K receptor CHEMBL4429 | Ki | 6.01 | 6.0033 | 983.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuromedin-K receptor | Ki | = | 983.0 | nM | 6.01 | Binding affinity towards cloned human Tachykinin receptor 3 (hNK-3) expressed in... | 10090788 |
| Neuromedin-K receptor | Ki | = | 1000.0 | nM | 6.0 | Displacement of [125I]-MePhe7-NKB from human NK3 receptor expressed in CHO cells... | 21047106 |
| Neuromedin-K receptor | Ki | = | 1000.0 | nM | 6.0 | Binding affinity to human NK3 receptor expressed in CHO cells | 22056747 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10090788 | 10.1021/jm980633c | Neuromedin-K receptor | 1 |
| 21047106 | 10.1021/jm1010012 | Neuromedin-K receptor | 1 |
| 22056747 | 10.1016/j.bmcl.2011.10.014 | Neuromedin-K receptor | 1 |
Data from ChEMBL 36 via Core Engine