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Assay Detail

CHEMBL1931471

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Binding
Binding affinity to human NK3 receptor expressed in CHO cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Neuromedin-K receptor (CHEMBL4429)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

3D-Quantitative structure-activity relationship and docking studies of the tachykinin NK3 receptor.
Geldenhuys WJ, Simmons MA.
Bioorg Med Chem Lett (2011) 21 : 7405 -7411
PubMed 22056747 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 23 6.98 8.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL10188 TALNETANT 2.0 1 8.60
CHEMBL10134 1 8.20
CHEMBL9645 1 8.20
CHEMBL10512 1 7.90
CHEMBL415968 1 7.80
CHEMBL268042 1 7.60
CHEMBL429951 1 7.50
CHEMBL10160 1 7.50
CHEMBL276386 1 7.30
CHEMBL275259 1 7.30
CHEMBL274163 1 7.30
CHEMBL418524 1 7.10
CHEMBL10517 1 6.80
CHEMBL9961 1 6.70
CHEMBL274763 1 6.60
CHEMBL274869 1 6.40
CHEMBL275316 1 6.30
CHEMBL9955 1 6.30
CHEMBL268046 1 6.30
CHEMBL9898 1 6.00
CHEMBL273975 1 6.00
CHEMBL10231 1 5.50
CHEMBL10333 1 5.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL10188 TALNETANT Ki = 2.512 nM 8.60
CHEMBL10134 Ki = 6.31 nM 8.20
CHEMBL9645 Ki = 6.31 nM 8.20
CHEMBL10512 Ki = 12.59 nM 7.90
CHEMBL415968 Ki = 15.85 nM 7.80
CHEMBL268042 Ki = 25.12 nM 7.60
CHEMBL429951 Ki = 31.62 nM 7.50
CHEMBL10160 Ki = 31.62 nM 7.50
CHEMBL276386 Ki = 50.12 nM 7.30
CHEMBL275259 Ki = 50.12 nM 7.30
CHEMBL274163 Ki = 50.12 nM 7.30
CHEMBL418524 Ki = 79.43 nM 7.10
CHEMBL10517 Ki = 158.49 nM 6.80
CHEMBL9961 Ki = 199.53 nM 6.70
CHEMBL274763 Ki = 251.19 nM 6.60
CHEMBL274869 Ki = 398.11 nM 6.40
CHEMBL275316 Ki = 501.19 nM 6.30
CHEMBL9955 Ki = 501.19 nM 6.30
CHEMBL268046 Ki = 501.19 nM 6.30
CHEMBL9898 Ki = 1000.0 nM 6.00
CHEMBL273975 Ki = 1000.0 nM 6.00
CHEMBL10231 Ki = 3162.28 nM 5.50
CHEMBL10333 Ki = 5011.87 nM 5.30