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Compound Detail

CHEMBL274869

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O=C(NC(CCO)c1ccccc1)c1cc(-c2ccccc2)nc2ccccc12

Basic Information

ChEMBL ID CHEMBL274869
Phase Preclinical
Structure Type MOL
InChI Key XTESXBGBBODSKW-UHFFFAOYSA-N
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

382.5
MW (Da)
4.76
ALogP
3
HBA
2
HBD
62.2
PSA (Ų)
0.51
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H22N2O2
MW 382.46
Aromatic Rings 4
Heavy Atoms 29
NP-Likeness -0.76

Activity Summary

Ki 3 meas. best 6.42

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Neuromedin-K receptor
CHEMBL4429
Ki 6.42 6.4067 382.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10090788 10.1021/jm980633c Neuromedin-K receptor 1
21047106 10.1021/jm1010012 Neuromedin-K receptor 1
22056747 10.1016/j.bmcl.2011.10.014 Neuromedin-K receptor 1

Data from ChEMBL 36 via Core Engine